NIH Announces $285 Million In New High-Risk, High-Reward Research Grants

National Institutes of Health (NIH) Announced on Tuesday, October 4 As part of that, we will award 103 new research grants totaling approximately $285 million over the next five years. High-Risk, High-Reward Research Program.

According to the NIH, high-risk, high-reward research programs Within the NIH mission, he is a highly creative scientist who pursues highly innovative research that may have broad implications for biomedical, behavioral, or social sciences. ”


This program is funded through NIH. common fund It is like an institution’s “venture capital” resource that invests in innovative research projects across different departments within the institution and can be overlooked in the traditional NIH peer review process due to its inherent risks. There is a possibility

In addition to the NIH Common Fund, the National Institute on Aging, the National Institute of General Medical Sciences, the National Institute of Mental Health, and the National Cancer Institute also supported the grant.

“The science advanced by these researchers is poised to open up new avenues of discovery in human health,” said Lawrence A. Tabak, DDS, Ph.D., acting director of the NIH. . “This unique group of scientists will change what we know in the world of biology and behavior. We are honored to support this groundbreaking science.”


The High-Risk, High-Reward Research Program oversees four award categories, two of which are specifically for researchers in the early stages of their careers. The four awards are:

Established in 2004, the NIH Directors’ Pioneer Awards encourage researchers at all career levels to pursue new research directions and to award groundbreaking and impactful research to a broad range of biomedical, behavioral, or social sciences. I am asking you to develop an approach.

  • NIH funded 8 Pioneer Awards 2022 includes a University of Colorado project developing a new animal model of HIV infection, which could lead to the development of a long-awaited HIV vaccine. A Duke University project is exploring new ways to rewire synapses with the potential to develop new treatments for mental illnesses such as depression, anxiety and addiction.

Established in 2007, the NIH Director’s New Innovator Award recognizes highly innovative research from early career researchers who are within 10 years of their final degree or clinical training and who have not yet received an NIH R01 or equivalent grant. to support


  • sum of 72 New Innovator Awards Developing new surgical techniques, studying how brain mechanisms affect working memory, investigating why women are more susceptible to Alzheimer’s disease, building bionic eyes for the permanently blind, exploring the physiology of hibernation Investigation, synthetic kidneys as an alternative to kidney transplantation.

Established in 2009, the NIH Director’s Transformative Research Award is open to individuals and teams of researchers who promote cross-cutting, interdisciplinary approaches and propose research that may create or challenge existing paradigms. increase.

  • 9 Transformational Research Awards It was created in areas such as precision cancer medicine, suicide prevention using various forms of digital technology, and pharmacotherapy for amyotrophic lateral sclerosis (ALS) disease.


Established in 2011, the NIH Director’s Early Independence Award is designed to help talented young researchers who have recently completed their Ph.D. We will provide you with the opportunity to help.

  • sum of 14 Early Independence Award They include research at the University of Washington in St. Louis on new therapeutic approaches for Alzheimer’s disease, the development of new vaccine technologies against coronavirus at the California Institute of Technology, and a method study at Vanderbilt University. Potassium deficiency contributes to chronic kidney disease.

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